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whole genome alignments and dotplot comparisons  (Broad Institute Inc)
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Broad Institute Inc whole genome alignments and dotplot comparisons
A) <t>Dotplot</t> comparison of pairwise alignments between whole-genome sequences from representatives of various Francisella subspecies is shown. The o-methyltransferase ortholog is highlighted on the Francisella tularensis subsp. holarctica strain 257 in orange (Y-axis) and on the Francisella tularensis subsp tularensis SchuS4 strain (X-axis, reference genome) in red. Blocks of synteny between each of the Francisella genomes compared to the Francisella tularensis subsp tularensis SchuS4 strain are plotted and rearrangements are indicated by breaks in the linearity of the lines and perpendicular orientations.
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A) Dotplot comparison of pairwise alignments between whole-genome sequences from representatives of various Francisella subspecies is shown. The o-methyltransferase ortholog is highlighted on the Francisella tularensis subsp. holarctica strain 257 in orange (Y-axis) and on the Francisella tularensis subsp tularensis SchuS4 strain (X-axis, reference genome) in red. Blocks of synteny between each of the Francisella genomes compared to the Francisella tularensis subsp tularensis SchuS4 strain are plotted and rearrangements are indicated by breaks in the linearity of the lines and perpendicular orientations.

Journal: PLoS ONE

Article Title: Host-Pathogen O-Methyltransferase Similarity and Its Specific Presence in Highly Virulent Strains of Francisella tularensis Suggests Molecular Mimicry

doi: 10.1371/journal.pone.0020295

Figure Lengend Snippet: A) Dotplot comparison of pairwise alignments between whole-genome sequences from representatives of various Francisella subspecies is shown. The o-methyltransferase ortholog is highlighted on the Francisella tularensis subsp. holarctica strain 257 in orange (Y-axis) and on the Francisella tularensis subsp tularensis SchuS4 strain (X-axis, reference genome) in red. Blocks of synteny between each of the Francisella genomes compared to the Francisella tularensis subsp tularensis SchuS4 strain are plotted and rearrangements are indicated by breaks in the linearity of the lines and perpendicular orientations.

Article Snippet: Whole genome alignments and dotplot comparisons are provided by the Broad Institute and the methodology for the Francisella comparative genome project is published .

Techniques: Comparison